Why choose CLEANMOOD®?
Clean label
Organic
CLEANMOOD® is the only branded 5-HTP sourced from certified Organic Griffonia Simplicifolia Seeds*
Glyphosate Free
CLEANMOOD® is certified glyphosate free by The Detox Project
Water Extracted
CLEANMOOD® is a water soluble & water extracted
Plant-Based
CLEANMOOD® is a plant-based and vegetarian ingredient
Clinically Studied Benefits
A branded form of organic 5-HTP
- CLEANMOOD® was clinically studied at 150 mg of 5-HTP daily for 25 days in 80 adults ages 18–40.*
- CLEANMOOD® supports mood and emotional well-being, with improved overall psychological distress scores.*
- CLEANMOOD® supports healthy sleep quality.*
- CLEANMOOD® supports a healthy physiological stress response, with reductions in morning and evening salivary cortisol.*
- Clinical benefits demonstrated in both capsule and functional food bar formats.*
- Well tolerated during the 25-day study, with no serious adverse events reported.*
Clinically Studied Mood + Sleep Quality Benefits
Beyond self-reported mood and sleep measures, the clinical study also evaluated morning and evening salivary cortisol, providing a physiological endpoint to complement the DASS-21 and PSQI findings.
After 25 days, CLEANMOOD® groups demonstrated significant reductions in both morning and evening salivary cortisol compared with their respective matched placebo groups.*
- Reduced morning and evening salivary cortisol after 25 days*
- Provides a physiological endpoint complementing the mood and sleep findings*
- Significant differences were observed versus matched placebo for both morning and evening cortisol*
Supporting a Healthy Physiological Stress Response
Beyond self-reported mood and sleep measures, the clinical study also evaluated morning and evening salivary cortisol, providing a physiological endpoint to complement the DASS-21 and PSQI findings.
After 25 days, CLEANMOOD® groups demonstrated significant reductions in both morning and evening salivary cortisol compared with their respective matched placebo groups.*
- Reduced morning and evening salivary cortisol after 25 days*
- Provides a physiological endpoint complementing the mood and sleep findings*
- Significant differences were observed versus matched placebo for both morning and evening cortisol*
Sustainable
CLEANMOOD® gives back to the community where the wild Griffonia Simplicifolia plants are harvested and maintained.
Versatile
CLEANMOOD® is offered in a versatile powder form that can be added to practically any application – with a shelf-life of two years, it has a neutral flavor, is water-soluble, and is heat and pH-stable.
Harvest Quality
We’re committed to keeping the environment as healthy as possible by abiding by certified organic practices and methods. That meant using clean water, clean soil, and zero pesticides throughout the planting, harvesting, and collecting process.
What is CLEANMOOD®?
CLEANMOOD® is a certified organic 5-HTP ingredient sourced from Griffonia simplicifolia seeds. It is designed for functional wellness products that support healthy mood, relaxation, stress balance, and sleep quality. Available in a versatile powder form, CLEANMOOD® is suitable for use in dietary supplements, functional foods, and beverages.
How does CLEANMOOD® work?
CLEANMOOD® delivers 5-HTP, a naturally occurring compound that serves as a direct precursor to serotonin production in the body. Serotonin is a key neurotransmitter involved in mood regulation, stress response, relaxation, and healthy sleep patterns. Because 5-HTP works directly within the serotonin pathway, CLEANMOOD® provides a clear, mechanism-based story for brands building products around mood, calm, and sleep.
What is the recommended daily dose of CLEANMOOD®?
What makes CLEANMOOD® different from other calming or mood-support ingredients?
CLEANMOOD® has a specific, well-understood mechanism. As a serotonin precursor, 5-HTP operates directly within a neurochemical pathway rather than providing broad, non-specific relaxation support. This gives brands a more targeted and substantiated positioning story. Beyond mechanism, CLEANMOOD® is differentiated by its organic certification, glyphosate-residue-free status, water extraction process, and non-GMO verification. It is also the only branded 5-HTP sourced from certified organic Griffonia simplicifolia, which adds a clean-label credential that most 5-HTP raw materials cannot match.
Can CLEANMOOD® be used in food and beverage products?
Yes. CLEANMOOD® Organic 5-HTP is designed for formulation versatility across dietary supplements, functional foods, and select beverage applications. Its water solubility, neutral flavor, and heat- and pH-stable properties make it suitable for capsules, powders, functional bars, snacks, and beverage mixes.
A published human clinical trial demonstrated significant improvements in psychological distress and sleep quality when CLEANMOOD® was delivered in both capsule and functional food bar formats, with comparable observed responses under the conditions tested.
For ready-to-drink beverages and other water-based applications, finished-product stability should be validated to confirm 5-HTP retention throughout shelf life. CLEANMOOD® has a stated shelf life of two years in its finished powder form.
Is CLEANMOOD® stable in finished products?
CLEANMOOD® is heat stable, pH stable, and water soluble with a neutral flavor profile, which supports its use across a wide range of product formats including bars, capsules, powders, and shots. These properties make it a practical choice for formulation across functional food and supplement categories. For ready-to-drink or water-based liquid applications, finished-product stability testing is recommended to confirm active 5-HTP retention under your specific storage and processing conditions.
Is CLEANMOOD® safe and well tolerated?
Yes. CLEANMOOD® Organic 5-HTP was well tolerated in a published, randomized, double-blind, placebo-controlled clinical trial involving 80 generally healthy adults ages 18–40. Participants received 150 mg/day of 5-HTP for 25 days, with no serious adverse events or clinically meaningful changes in measured vital signs, hematological parameters, or serum chemistry markers.
5-HTP also has an established history of clinical research. Important considerations include potential gastrointestinal sensitivity at higher doses and avoiding concurrent use with serotonergic medications unless directed by a healthcare professional.
Where does CLEANMOOD® come from, and how is it made?
CLEANMOOD® is sourced from the seeds of Griffonia simplicifolia, a woody climbing shrub native to West and Central Africa and one of the richest natural plant sources of 5-HTP. The seeds are grown under certified organic practices with no synthetic pesticides, herbicides, or glyphosate, and 5-HTP is extracted using a water-based process that preserves the clean-label integrity of the finished ingredient.
